Thermo Fisher Scientific Arginase 1 Polyclonal Antibody
Thermo Fisher Scientific의 Arginase 1 Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 토끼 IgG 항체로, Western blot, IHC, ELISA 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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- PA529645
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 | 14 |
| Immunohistochemistry (IHC) | – | 21 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 | 1 |
| Immunohistochemistry (Frozen) (IHC-F) | – | 1 |
| Immunocytochemistry (ICC/IF) | Assay-dependent | 4 |
| Flow Cytometry (Flow) | – | 1 |
| ELISA | 1:1,000–1:10,000 | 1 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 1–175 of Human Arginase I |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.41 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547120 |
Product Specific Information
- Recommended positive controls: Mouse liver, Rat liver
- Predicted reactivity: Mouse (85%), Rat (83%), Pig (90%), Rabbit (90%), Bovine (89%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme that catalyzes the conversion of L-arginine to urea and L-ornithine, representing the final step in the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification. Arginase 1 down-regulates nitric oxide production by depleting NO synthase substrate.
In humans and mice, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In mice, it is a hallmark of alternatively activated macrophages (M2a). Arginase 1 is also often found in hepatocellular carcinomas and myeloid cells infiltrating tumors.
Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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