Thermo Fisher Scientific Phospho-RBM4 (Ser309) Polyclonal Antibody, Biotin
Phospho-RBM4 (Ser309) 폴리클로날 항체로, Biotin 결합형 제품입니다. Western blot, ELISA, Immunoprecipitation 등 다양한 응용에 사용 가능하며, 사람·생쥐·랫트 반응성을 가집니다. 고순도 친화 크로마토그래피 정제, 안정적 저장 버퍼 제공.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phosphorylated synthetic peptide within amino acid region 300–350 of human RNA binding motif protein 4 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
RNA-binding factor involved in multiple aspects of cellular processes such as alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5′-splice site and exon selection, and acts as a muscle cell differentiation-promoting factor. Activates exon skipping of PTB pre-mRNA during muscle cell differentiation and antagonizes PTBP1 to modulate muscle-specific exon selection of alpha tropomyosin.
Binds intronic pyrimidine-rich sequences of TPM1 and MAPT pre-mRNAs, required for translational activation of PER1 mRNA in response to circadian rhythm. Suppresses cap-dependent translation via CU-rich elements within 3′UTR under stress or during myocyte differentiation. Recruits EIF4A1 for IRES-dependent translation initiation under stress.
Associates with internal ribosome entry segments (IRES) and miRNA-guided RNA cleavage complexes (AGO2-miRNPs). Plays a role in muscle cell differentiation and preferentially binds to 5′-CGCGCG[GCA]-3′ motif in vitro.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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