Thermo Fisher Scientific Phospho-MCL1 (Ser159, Thr163) Polyclonal Antibody
인간 MCL1 단백질의 인산화된 Ser159 및 Thr163 잔기를 인식하는 폴리클로날 항체입니다. Western blot에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 보존제가 없으며 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA517125
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Phospho-MCL1 (Ser159, Thr163) Polyclonal Antibody
Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding human pSer159/Thr163 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979978 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
MCL1 (Myeloid cell leukemia-1) belongs to the Bcl-2 family and is involved in differentiation and maintenance of cell viability. Isoform 1 inhibits apoptosis, while isoform 2 promotes it. MCL1 expression increases upon DNA damage and is associated with mitochondria. It promotes cell viability under apoptotic conditions, possibly by neutralizing pro-apoptotic Bcl-2 family members such as Bim or Bak. MCL1 is essential for embryogenesis and lymphocyte development, existing in two isoforms: MCL1L and MCL1S. Overexpression of MCL1S promotes cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-17125_MCL-1_Q07820-1_Rabbit.svg, PA5-17125_MCL-1_Q07820-1_Rabbit_PDP.jpeg)
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