Thermo Fisher Scientific SMAD1 Polyclonal Antibody
SMAD1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot, IP, ChIP assay에 적합합니다. Human, Mouse, Non-human primate 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunoprecipitation (IP) | 1:100 | View 1 publication |
| ChIP assay (ChIP) | 1:25 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Ser190 of human Smad1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 83 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10980026 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The SMAD1 protein belongs to the SMAD family, which includes proteins homologous to Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma. SMAD proteins act as signal transducers and transcriptional modulators in multiple signaling pathways. SMAD1 mediates bone morphogenetic protein (BMP) signals involved in cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP ligand stimulation, SMAD1 is phosphorylated by BMP receptor kinase and forms a complex with SMAD4, essential for transcriptional regulation. It is also a target for SMAD-specific E3 ubiquitin ligases (SMURF1, SMURF2), leading to ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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