Thermo Fisher Scientific ARTS1 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 10–12.5 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Marmoset (100%)
Orangutan, Hamster (93%)
Dog, Bovine, Rabbit, Horse, Pig (87%)

Target Information

The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) is a 120 kDa protein localized to the lumen of the ER, which removes NH₂-terminal residues from many antigenic precursors for MHC class I peptide presentation. Peptides presented by MHC class I on the cell surface must be 8–11 residues long, and ERAP1 specifically trims peptides of 9 amino acids or more. ERAP1 is also induced by interferon-gamma. The gene encoding human ERAP1 maps to chromosome 5q15.

ERAP1 has been characterized as:

• A-LAP (Adipocyte-derived leucine aminopeptidase): Inactivates bioactive peptides such as angiotensin II, potentially regulating blood pressure.
• PILS-AP (Puromycin-insensitive leucine-specific aminopeptidase): Plays a role in angiogenesis by regulating endothelial cell proliferation and migration.
• ARTS-1 (Aminopeptidase regulator of TNFR1 shedding): Acts as a TNFR1 binding protein promoting TNFR1 shedding.

Further research is needed to fully elucidate the functions of this protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.