Thermo Fisher Scientific ASH2L Monoclonal Antibody (OTI2H3)
ASH2L 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, WB 및 IHC(P) 실험에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 고순도 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H3 |
| Immunogen | Human recombinant protein fragment (aa 347–628 of ASH2L, produced in E. coli) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2722881 |
Target Information
The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1 (isoform 1), containing a nuclear localization signal and PHD finger motif, suggesting a role as a transcription regulator.
Predicted molecular weight: 68.7 kDa.
Alternative splicing may produce isoforms of 60 kDa and 56.5 kDa.
Human ASH2L proteins are:
- 60% homologous to Drosophila ash2, which regulates gene expression in early development.
- 90% homologous to mouse ASH2L.
Expression profile:
- Predominantly in adult heart and testis, and fetal lung and liver.
- Barely detectable in adult lung, liver, kidney, prostate, and peripheral leukocytes.
- Expressed in leukemia cell lines (K562, Hel, Dami) with erythroid and megakaryocytic potential.
Differentiation inducers (e.g. phorbol ester, hemin) alter expression patterns, indicating ASH2L’s role in hematopoiesis and leukemia association.
ASH2L may interact with beta-tubulin and beta-catenin.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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