Thermo Fisher Scientific Phospho-Sphingosine 1-Phosphate Receptor 3 (Ser335, Ser337) Polyclonal Antibody
인산화된 S1P3 수용체(Ser335/Ser337)에 특이적인 Rabbit Polyclonal 항체로, Western blot에 최적화됨. Human 시료 반응성. 항원 친화 크로마토그래피로 정제. 액상 형태, 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human S1P3 around the phosphorylation site of Ser335/Ser337 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
EDG-3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids.
The ligand for EDG-3 is sphingosine-1-phosphate.
There are 8 known members of the EDG receptor family, implicated in mediating growth-related effects such as:
- Induction of cellular proliferation
- Alterations in differentiation and survival
- Suppression of apoptosis
They also evoke cellular effector functions dependent on cytoskeletal responses such as contraction, secretion, adhesion, and chemotaxis.
EDG receptors are developmentally regulated, differ in tissue distribution, and couple to multiple G proteins to signal through Ras, MAP kinase, Rho, phospholipase C, and several protein tyrosine kinases.
EDG-3 is expressed in cardiovascular, leukocyte-containing, and other tissues.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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