Thermo Fisher Scientific VISTA Monoclonal Antibody (027)
인간 VISTA 단백질을 인식하는 mouse monoclonal antibody입니다. IHC(P)에서 1:30~1:100 희석으로 사용됩니다. 보존제가 없는 액상 형태이며, Protein A로 정제되었습니다. 암면역 연구 등 T세포 억제 관련 연구에 활용 가능합니다.
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- MA529643
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:30–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 027 |
| Immunogen | Recombinant Human VISTA/GI24/B7-H5 Protein (Met1–Ala194) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785470 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human VISTA/GI24/B7-H5.
Target Information
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1, it has a different expression pattern. In both mouse and human, VISTA is expressed predominantly on hematopoietic cells, with the highest densities on myeloid cells and lower levels on T cells, and is usually absent on B cells.
VISTA expressed by antigen-presenting cells can directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. Reported ligands of VISTA include CD28H, VSIG-3, and VSIG-8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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