Thermo Fisher Scientific RYBP Monoclonal Antibody (OTI2H9), TrueMAB
RYBP 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 Flow cytometry에 적합. Human 시료에 반응하며, 고순도 Affinity chromatography로 정제됨. PBS/BSA/glycerol buffer에 보관되며 -20°C에서 안정적 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H9 |
| Immunogen | Full length human recombinant protein of human RYBP produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
RYBP is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, which maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG PRC1-like complex acts via chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A (Lys-119), leading to heritable changes in chromatin expressibility.
It is involved in X chromosome inactivation in females and may stimulate histone H2A ubiquitination by recruiting the complex to target sites. RYBP inhibits ubiquitination and degradation of TP53, thereby regulating transcription of TP53 target genes, and may also influence proteasomal degradation of other proteins such as FANK1, contributing to apoptosis regulation. It may act as a transcriptional repressor and play a role in suppression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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