Thermo Fisher Scientific ME2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ME2. Recombinant protein control fragment (Product #RP-88954). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ME2,uniProtId:P23368-1,ncbiNodeId:9606,antigenRange:296-424,antigenLength:584,antigenImageFileName:PA5-52621_ME2_P23368-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52621_ME2_P23368-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2643835

Product Specific Information

Immunogen sequence: KVISKPISEH KILFLGAGEA ALGIANLIVM SMVENGLSEQ EAQKKIWMFD KYGLLVKGRK AKIDSYQEPF THSAPESIPD TFEDAVNILK PSTIIGVAGA GRLFTPDVIR AMASINERPV IFALSNPTA

Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 80%.

Target Information

ME2 encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.