Thermo Fisher Scientific GP130 Monoclonal Antibody (8D4D2)
GP130 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC, Flow cytometry, ELISA에 적합합니다. Human 및 비인간 영장류에 반응하며, Protein G로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8D4D2 |
| Immunogen | Purified recombinant fragment of human CD130 (aa 73–231) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898381 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
The GP130 protein acts as a signal transducer shared by multiple cytokines, including IL6, CNTF, LIF, and OSM. It functions as part of the cytokine receptor complex, with activation dependent on cytokine-receptor binding. Viral IL6 (vIL6) from Kaposi sarcoma-associated herpesvirus can directly activate GP130 without IL6R. Knockout studies in mice indicate its critical role in regulating myocyte apoptosis. Multiple alternatively spliced isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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