Thermo Fisher Scientific TPL2 Polyclonal Antibody
Rabbit polyclonal antibody against human MAP3K8 (TPL2). Validated for IHC (paraffin) at 15 µg/mL. Reacts with human, bovine, and non-human primate. Affinity purified, liquid form, 1 mg/mL. For research use only.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 15 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from near N-terminus of human MAP3K8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551283 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Marmoset, Bovine (100%)
Hamster, Panda, Bat, Dog (95%)
Mouse, Rat, Rabbit, Pig (89%)
Target Information
MAP3K8 (COT) is a serine/threonine kinase that activates both MAP and JNK kinase pathways and plays a role in the cell cycle.
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK.
These kinases are highly conserved, with homologs in yeast, Drosophila, and mammalian cells.
MEKK8 activates NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105.
This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines.
The 58 kDa form is activated during the S and G2/M phases of the cell cycle.
The longer form undergoes phosphorylation mainly on Ser residues, and the shorter form on both Ser and Thr residues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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