Thermo Fisher Scientific MLK1 Polyclonal Antibody
MLK1 단백질을 표적하는 Rabbit Polyclonal Antibody로 MAP3K9 신호전달 연구에 적합. 다양한 종에 반응하며 IHC(Paraffin) 응용에 검증됨. 고순도 항원 친화 크로마토그래피로 정제된 액상 형태 제품.
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Thermo Fisher Scientific MLK1 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 7–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Horse, Human, Mouse, Non-human primate, Rabbit |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from internal region of human MAP3K9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551284 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Panda, Dog, Horse, Rabbit (100%)
Hamster, Elephant, Bovine, Bat, Pig (94%).
Target Information
MAP3K9 (MLK1) is a serine/threonine protein kinase that functions in the MAP kinase pathway. It plays an important role in cellular response cascades evoked by environmental changes. Once activated, it acts as an upstream activator of the MKK/JNK signal transduction cascade through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. MLK1 also participates in mitochondrial death signaling pathways, including cytochrome c release leading to apoptosis.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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