Thermo Fisher Scientific OPRL1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1.0 µg/mL
• View 1 publication

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100%

Target Information

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600–1,000 members and is the largest known class of molecular targets with proven therapeutic value.
The nociceptin receptor is a G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors.
Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases.
Plays a role in modulating nociception and the perception of pain, and in the regulation of locomotor activity by the neuropeptide nociceptin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.