Thermo Fisher Scientific PCSK2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Target Information

The subtilisin-like prohormone convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins transported by the constitutive secretory pathway are also targeted for maturation by PCs.
PC family members share structural similarities, including:

• A heterogeneous ~10 kDa amino-terminal proregion
• A highly conserved ~55 kDa subtilisin-like catalytic domain
• A carboxyl-terminal domain heterogeneous in length and sequence

These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment.
Immunolocalization studies show that PC1 is found in the perinuclear region and the trans-Golgi network, whereas PC2 is present in the trans-Golgi network and diffusely distributed in the peripheral cytoplasm.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.