Thermo Fisher Scientific Phospho-HDAC4/HDAC5/HDAC9 (Ser246, Ser259, Ser220) Recombinant Rabbit Monoclonal Antibody (8H4J9)
HDAC4, HDAC5, HDAC9의 인산화 부위를 인식하는 재조합 토끼 단클론 항체입니다. WB, IHC, ELISA에 사용 가능하며, 인간, 생쥐, 랫트 시료에 반응합니다. 고순도의 친화 크로마토그래피 정제 제품으로, 안정한 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8H4J9 |
| Immunogen | A phospho synthetic peptide corresponding to residues surrounding S246 & S259 & S220 of Human HDAC4, HDAC5, and HDAC9. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.84 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3094411 |
Target Information
Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. Eight members of the HDAC family have been identified and are divided into two classes, I and II.
Class I includes HDAC-1, 2, 3, and 8, which share 45–93% sequence identity in their deacetylase domains.
Class II includes HDAC-4, 5, 6, and 7, which are approximately twice as large and have deacetylase domains in the C-terminal regions (HDAC-6 has two such domains).
While HDAC-1, 2, and 3 are broadly expressed, HDAC-4, 5, 6, and 7 show tissue-specific patterns, indicating distinct substrate specificities and biological roles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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