Thermo Fisher Scientific Phospho-HDAC4/HDAC5/HDAC9 (Ser246, Ser259, Ser220) Recombinant Rabbit Monoclonal Antibody (8H4J9)

Applications and Tested Dilutions

Product Specifications

Target Information

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. Eight members of the HDAC family have been identified and are divided into two classes, I and II.
Class I includes HDAC-1, 2, 3, and 8, which share 45–93% sequence identity in their deacetylase domains.
Class II includes HDAC-4, 5, 6, and 7, which are approximately twice as large and have deacetylase domains in the C-terminal regions (HDAC-6 has two such domains).
While HDAC-1, 2, and 3 are broadly expressed, HDAC-4, 5, 6, and 7 show tissue-specific patterns, indicating distinct substrate specificities and biological roles.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.