Thermo Fisher Scientific HRI Polyclonal Antibody
HRI 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, Human 및 Mouse 시료에 반응. WB 및 ICC/IF에 사용 가능하며, 고순도 affinity chromatography로 정제. 1 mg/mL 농도, PBS+50% glycerol buffer에 보관.
- 카탈로그번호
- PA5115166
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human EIF2AK1 (Accession Q9BQI3), corresponding to amino acid residues I575–K625 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899802 |
Product Specific Information
Antibody detects endogenous levels of total EIF2AK1.
Target Information
EIF2AK1 (HRI) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein synthesis.
In the case of EIF2AK1, signaling is initiated by low levels of heme.
The HRI gene is localized to 7p22 where its 3′ end slightly overlaps the 3′ end of the gene JTV1.
The two genes are transcribed from opposite strands, and kinase activity is induced by low levels of heme and inhibited by the presence of heme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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