Thermo Fisher Scientific CD20/ MS4A1 (B-Cell Marker) Monoclonal Antibody (MS4A1/3411)
CD20(B-cell marker)을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용에 사용 가능. 인간 시료 반응성, Protein A/G 정제, 4°C 보관, 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| ELISA | 2–4 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MS4A1/3411 |
| Immunogen | Recombinant fragment (aa 213–297) of human MS4A1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD20 is a non-glycosylated surface phosphoprotein with a molecular weight of 33–37 kDa depending on phosphorylation. It is expressed on mature and most malignant B cells, a subset of T lymphocytes, and follicular dendritic cells.
CD20 expression coincides with surface IgM expression and regulates calcium conductance, cell cycle progression, and B-cell proliferation. It associates with lipid rafts, and its localization changes upon extracellular stimulation or BCR aggregation.
Following receptor ligation, BCR and CD20 initially colocalize and then separate before BCR endocytosis, while CD20 remains on the surface.
CD20 is a key therapeutic target for antibody-mediated B-cell depletion, as it is highly expressed on B-cell malignancies and remains on the plasma membrane after treatment.
Diseases associated with CD20 dysfunction include MS4A1-related common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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