Thermo Fisher Scientific SPP1 Monoclonal Antibody (3G11)
SPP1 단백질을 표적으로 하는 마우스 단클론 항체로, Western blot과 ELISA에 적합합니다. 인간 시료에 반응하며, 비결합형 액상 형태로 제공됩니다. 골단백질(Osteopontin) 연구 및 세포 부착·염증 관련 연구에 유용합니다.
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Thermo Fisher Scientific SPP1 Monoclonal Antibody (3G11)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G11 |
| Immunogen | SPP1 (NP_000573, 148–257 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SVVYGLRSKS KKFRRPDIQY PDATDEDITS HMESEELNGA YKAIPVAQDL NAPSDWDSRG KDSYETSQLD DQSAETHSHK QSRLYKRKAN DESNEHSDVI DSQELSKVSR
Target Information
Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease, and transformation.
Proteolytic cleavage by thrombin and matrix metalloproteinases near the integrin-binding Arg-Gly-Asp sequence modulates the function and integrin binding properties of OPN.
Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors, providing a molecular niche with survival advantage and serving as substrates for plasmin and cathepsin D.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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