Thermo Fisher Scientific CD274 Monoclonal Antibody (2E6)
CD274 (PD-L1) 단백질을 인식하는 Mouse Monoclonal Antibody (Clone 2E6). Western blot 및 ELISA에 적합. Human 시료 반응성. PBS buffer에 보관되며, -20°C에서 저장 권장. 종양 면역 회피 연구에 활용 가능.
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- H00029126-M04
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E6 |
| Immunogen | CD274 (AAH74984.1, 18 a.a. – approximately 238 a.a.) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
AFTVTVPKDL YVVEYGSNMT IECKFPVEKQ LDLAALIVYW EMEDKNIIQF VHGEEDLKVQ HSSYRQRARL LKDQLSLGNA ALQITDVKLQ DAGVYRCMIS YGGADYKRIT VKVNAPYNKI NQRILVVDPV TSEHELTCQA EGYPKAEVIW TSSDHQVLSG KTTTTNSKRE EKLFNVTSTL RINTTTNEIF YCTFRRLDPE ENHTAELVIP ELPLAHPPNE R
Target Information
Programmed death receptor ligand 1 (PD-L1, also known as B7-H1) is a member of the B7 family. PD-L1 binds to the receptor PD-1, which negatively regulates T-cell receptor (TCR) signaling. Upon binding, PD-L1 decreases TCR-mediated proliferation and cytokine production. PD-L1 is abundantly expressed on many murine and human cancers and is up-regulated upon IFN-gamma stimulation, suggesting its role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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