Thermo Fisher Scientific CD274 Monoclonal Antibody (2E11)
인간 PD-L1(CD274)을 인식하는 Mouse IgG2b 단일클론 항체로, Western blot 및 ELISA에 적합합니다. 액상 형태로 제공되며, PBS(pH 7.4) buffer에 보존제가 없습니다. -20°C에서 보관하며, 종양 면역회피 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E11 |
| Immunogen | CD274 (AAH74984.1, 18–238 a.a.) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
AFTVTVPKDL YVVEYGSNMT IECKFPVEKQ LDLAALIVYW EMEDKNIIQF VHGEEDLKVQ HSSYRQRARL LKDQLSLGNA ALQITDVKLQ DAGVYRCMIS YGGADYKRIT VKVNAPYNKI NQRILVVDPV TSEHELTCQA EGYPKAEVIW TSSDHQVLSG KTTTTNSKRE EKLFNVTSTL RINTTTNEIF YCTFRRLDPE ENHTAELVIP ELPLAHPPNE R
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a B7 family member that binds to programmed death receptor 1 (PD-1), a negative regulator of T-cell receptor (TCR) signaling. Upon PD-L1/PD-1 interaction, TCR-mediated proliferation and cytokine production are reduced. PD-L1 is abundantly expressed in many murine and human cancers and can be upregulated by IFN-γ stimulation, suggesting a role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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