Thermo Fisher Scientific CD122 Polyclonal Antibody
Rabbit polyclonal antibody against human CD122 for IHC (paraffin) applications. High specificity and affinity-purified by antigen chromatography. Supplied in PBS with 40% glycerol and sodium azide. For research use only.
- 카탈로그번호
- PA5111552
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested dilution: 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CD122 (Product # RP-102008) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856962 |
Product Specific Information
Immunogen sequence:
DRRRWNQTCE LLPVSQASWA CNLILGAPDS QKLTTVDIVT LRVLCREGVR WRVMAIQ
Target Information
CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses and is primarily expressed in the hematopoietic system. It exists in three forms:
- Low affinity form: Alpha subunit monomer, not involved in signal transduction
- Intermediate affinity form: Alpha/beta heterodimer
- High affinity form: Alpha/beta/gamma heterotrimer
Both intermediate and high affinity forms mediate receptor endocytosis and mitogenic signal transduction.
The CD122 gene encodes the beta subunit, a type I membrane protein.
Dysfunction of CD122 is associated with oligoarticular juvenile idiopathic arthritis and rheumatoid factor-negative juvenile idiopathic arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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