Thermo Fisher Scientific IL-10 Polyclonal Antibody
IL-10 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 시료에 반응합니다. WB, IHC, ELISA 등 다양한 응용에 사용 가능합니다. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL | - |
| ELISA | 0.1–0.5 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived human IL-10 recombinant protein (Position: S19–N178) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746573 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes.
This cytokine plays a key role in immunoregulation and inflammation by down-regulating the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages.
It enhances B cell survival, proliferation, and antibody production, and can block NF-kappa B activity.
IL-10 is involved in the regulation of the JAK-STAT signaling pathway.
Knockout studies in mice indicate that IL-10 is an essential immunoregulator in the intestinal tract.
Mutations in IL10 are associated with increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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