Thermo Fisher Scientific Lass4 Polyclonal Antibody
LASS4 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 인간 단백질에 반응하며, Affinity chromatography로 정제됨. PBS buffer에 50% glycerol 포함, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CERS4 (Accession Q9HA82), corresponding to amino acid residues L49–Q99 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2850700 |
Product Specific Information
Antibody detects endogenous levels of total LASS4.
Target Information
The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family (LASS1–LASS6) are involved in sphingolipid synthesis.
LASS4 is a 394-amino-acid endoplasmic reticulum multi-pass membrane protein that increases the levels of long ceramides such as C22:0 and C24:0 ceramides.
In CLN9-deficient cells, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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