Thermo Fisher Scientific Fibronectin Monoclonal Antibody (3F12)

Thermo Fisher Scientific Fibronectin Monoclonal Antibody (3F12)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-14737 has been successfully used in WB, ELISA, immunofluorescence, immunoprecipitation, and radioimmune assay applications, and reacts with human samples.
MA5-14737 detects Fibronectin with a predicted molecular weight of approximately 259 kDa.
Product MA514737 is a smaller package size of MIF2601 (formerly sold as a Seradyn product).

Target Information

Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble, cross-linked protein forming high molecular mass polymers. It is most abundant during embryonic development and tissue remodeling.

Fibronectin is also present at high concentrations as a soluble plasma protein and organized as a linear series of repeating modules forming domains for interaction with fibronectin itself, other matrix components (e.g., collagen, heparin), and cell receptors (e.g., integrins).

It plays critical roles in:

• Cell adhesion and migration
• Embryogenesis and wound healing
• Blood coagulation and host defense
• Metastasis and carcinoma development, particularly in non-small cell lung cancer

Fibronectin gene has three regions subject to alternative splicing, potentially producing 20 different transcript variants, though the full-length nature of some variants remains undetermined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.