Thermo Fisher Scientific Fumarase Polyclonal Antibody
Thermo Fisher Scientific의 Fumarase Polyclonal Antibody는 인간 시료에 반응하며, Western blot과 IHC(P) 분석에 적합합니다. Goat에서 유래한 Polyclonal IgG로, 합성 펩타이드 항원을 면역원으로 사용합니다. 0.5 mg/mL 농도의 액상 제품으로, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.01–0.03 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3.75 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (HPNDHVNKSQSSND) corresponding to the internal amino acids of FH (aa 176–190) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_11006491 |
Product Specific Information
- Predicted to react with canine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (Krebs) cycle and catalyzes the formation of L-malate from fumarate.
It exists in both cytosolic and N-terminal extended mitochondrial forms, differing by translation start site.
The mitochondrial form undergoes cleavage to produce the same mature form as in the cytoplasm.
This enzyme functions as a homotetramer and shares similarity with thermostable class II fumarases.
Mutations in this gene can cause fumarase deficiency, leading to progressive encephalopathy.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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