Thermo Fisher Scientific USP7 Monoclonal Antibody (OTI1F12), TrueMAB
USP7 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC, Flow cytometry에 적합. Human 시료 반응성. Lyophilized 형태로 제공되며, PBS buffer와 trehalose 포함. p53 관련 종양 억제 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F12 |
| Immunogen | Full length human recombinant USP7 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve an antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
USP7 (also known as HAUSP) is a ubiquitin-specific protease that removes ubiquitin from substrate proteins.
It stabilizes target proteins by preventing their degradation via the ubiquitin-proteasome pathway.
USP7 is a known antagonist of Mdm2, the E3 ubiquitin ligase for p53, thereby stabilizing p53 under stress conditions.
This mechanism suggests a potential tumor suppressor role for USP7.
Additionally, USP7 is implicated in oncogenic pathways involving Myc and E1A, potentially acting through ARF-dependent or independent mechanisms to modulate p53 stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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