Thermo Fisher Scientific USP7 Monoclonal Antibody (OTI1F12), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve an antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

USP7 (also known as HAUSP) is a ubiquitin-specific protease that removes ubiquitin from substrate proteins.
It stabilizes target proteins by preventing their degradation via the ubiquitin-proteasome pathway.
USP7 is a known antagonist of Mdm2, the E3 ubiquitin ligase for p53, thereby stabilizing p53 under stress conditions.
This mechanism suggests a potential tumor suppressor role for USP7.
Additionally, USP7 is implicated in oncogenic pathways involving Myc and E1A, potentially acting through ARF-dependent or independent mechanisms to modulate p53 stability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.