Thermo Fisher Scientific CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), eFluor 450, eBioscience
CD49f (Integrin α6) 단백질을 인식하는 eBioGoH3 단클론 항체로, 인간 및 생쥐 세포에 반응합니다. eFluor 450 형광 표지로 유세포분석에 최적화되어 있으며, 라미닌 결합 차단 기능을 가집니다. 405 nm 레이저로 여기, 445 nm에서 방출됩니다.
- 카탈로그번호
- 48-0495-8x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), eFluor 450, eBioscience
Thermo Fisher Scientific CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), eFluor 450
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 4 publications |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.125 µg/test | View 47 publications |
| Neutralization (Neu) | - | View 2 publications |
Product Specifications
| Specification | Detail |
|---|---|
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), eFluor™ 450 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioGoH3 (GoH3) |
| Conjugate | eFluor™ 450 |
| Excitation / Emission Max | 405 / 445 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Wet ice |
| RRID | AB_11040527 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- FITC
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 780
- Request custom conjugation
Product Specific Information
Description:
The eBioGoH3 monoclonal antibody reacts with mouse and human CD49f (integrin alpha 6), also known as VLA-6 alpha chain or platelet gpIc. CD49f is a 120 kDa transmembrane protein that associates with CD29 (integrin beta 1) to form VLA-6 and with CD104 (integrin beta 4) to form the α6β4 complex. It is expressed on T cells, monocytes, platelets, epithelial and endothelial cells, and germinal center B cells.
The antibody is cross-reactive with human, mouse, and bovine integrin alpha 6 and can block laminin binding.
Applications Reported:
Suitable for flow cytometric analysis.
Applications Tested:
Validated for flow cytometry on normal human peripheral blood cells. Recommended usage ≤0.125 µg/test (100 µL final volume, 10⁵–10⁸ cells/test). Optimize titration for best results.
Fluorophore Information:
eFluor® 450 is an alternative to Pacific Blue®, excited at 405 nm and emits at 445 nm (Violet laser compatible).
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
CD49f (Integrin alpha-6, ITGA6) is an integrin alpha chain that combines with beta chains to form various integrins such as α6β4 (TSP180) and α6β1 (VLA-6). Integrins mediate cell adhesion and signaling, influencing cellular shape, mobility, and proliferation.
They link extracellular matrix (ECM) components to intracellular cytoskeletal proteins and integrate with growth factor signaling.
CD49f is mainly expressed in epithelial cells and plays a structural role in hemidesmosomes. Over 18 alpha and 8 beta subunits with multiple splice variants are known in mammals.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.