Thermo Fisher Scientific Phospho-HER4 (Tyr1056) Polyclonal Antibody
Phospho-HER4 (Tyr1056) 항체로 인간, 마우스, 랫트 시료에 반응합니다. IHC, ICC, ELISA 등 다양한 응용에 적합하며, Rabbit Polyclonal 형식입니다. Protein A로 정제된 고순도 항체로 -20°C에서 안정적으로 보관 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human HER4 around the phosphorylation site of Tyr1056 [PA (p-Y)TP] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine kinase subfamily, which includes EGFR, ERBB2, and ERBB3. ERBB4 binds and is activated by neuregulins and other ligands, inducing various cellular responses such as mitogenesis and differentiation. It mediates signal transduction related to cell metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, apoptosis, and differentiation.
ERBB4 is predominantly expressed in several breast carcinoma cell lines and in normal tissues such as skeletal muscle, heart, pituitary, brain, and cerebellum. High expression levels are observed in breast tumor cell lines T47-D, MDA-MB-453, BT-474, and H3396, while lower or absent expression is seen in MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3. Elevated ERBB4 levels in certain tumor cell lines suggest a potential role in malignancy.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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