Thermo Fisher Scientific Phospho-HER4 (Tyr1258) Polyclonal Antibody
Phospho-HER4 (Tyr1258) 폴리클로날 항체로, 인간·마우스·랫트에 반응하며 다양한 IHC, ICC, ELISA 실험에 적합합니다. Rabbit IgG 기반으로 Protein A 정제, 1 mg/mL 농도. HER4 신호전달 연구 및 종양 관련 단백질 분석에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human HER4 around phosphorylation site Tyr1258 [PD(p-Y)LQ] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine kinase subfamily that includes EGFR, ERBB2, and ERBB3.
ERBB4 binds and is activated by neuregulins and other factors, inducing various cellular responses such as mitogenesis and differentiation.
ErbB4 mediates signal transduction in eukaryotic cells, regulating metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.
ErbB4 is predominantly expressed in several breast carcinoma cell lines and in normal skeletal muscle, heart, pituitary, brain, and cerebellum.
High mRNA levels are found in T47-D, MDA-MB-453, BT-474, and H3396 cell lines, while intermediate levels are seen in MCF-7, MDAMB-330, and MDA-MB-361.
Expression is low or absent in MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.
Elevated ErbB4 levels in certain tumor cell lines suggest a potential role in malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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