Thermo Fisher Scientific FZD8 Polyclonal Antibody
FZD8 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC(P) 분석에 적합. 고농도(1 mg/mL) 액상 형태로 제공되며, 인간, 마우스, 랫드 등에서 반응 예측됨. 연구용으로 다양한 암 관련 신호전달 연구에 활용 가능.
- 카탈로그번호
- PA528081
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 634–694 of Frizzled 8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545557 |
Product Specific Information
- Recommended positive control: H1299
- Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Members of the Frizzled family encode seven-transmembrane domain proteins that act as receptors for the Wingless-type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway.
Frizzled 8 is highly expressed in certain human cancer cell lines, suggesting a role in cancer-related pathways. Expression has been reported in brain, heart, kidney, pancreas, and skeletal muscle. ESTs have been isolated from various tissues and tumor libraries. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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