Thermo Fisher Scientific GNAS (R201H Mutant) Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000–1:10,000

Product Specifications

Product Specific Information

Store as concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, aliquot and store at -20°C or below.
Avoid multiple freeze-thaw cycles.

Target Information

This locus has a highly complex imprinted expression pattern, giving rise to maternally, paternally, and biallelically expressed transcripts derived from four alternative promoters and 5′ exons.
Some transcripts contain a differentially methylated region (DMR) at their 5′ exons, commonly found in imprinted genes and correlated with transcript expression.
This gene has an antisense transcript; both the antisense and one of the transcripts are paternally expressed noncoding RNAs that may regulate imprinting in this region.
Additionally, one transcript contains a second overlapping ORF encoding a structurally unrelated protein (Alex).
Alternative splicing of downstream exons results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with activation of adenylyl cyclase.
Additional transcript variants have been found, though some are of uncertain biological validity.
[provided by RefSeq, Jun 2015]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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