Thermo Fisher Scientific CD33 Monoclonal Antibody (WM53), FITC

Thermo Fisher Scientific CD33 Monoclonal Antibody (WM53), FITC

Applications

• Flow Cytometry (Flow)

Tested Dilution: 4 µL/1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• APC
• PE
• PerCP
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with an extracellular epitope of CD33, a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells, and mast cells. It is absent on platelets, lymphocytes, erythrocytes, and hematopoietic stem cells.

Target Information

CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatases SHP-1 and SHP-2, mediating inhibitory signaling and receptor removal via ubiquitination.
CD33 is expressed on myelomonocytic lineage cells and binds sialic acid residues on cell surfaces. It is a therapeutic and diagnostic marker for acute myeloid leukemia (AML), expressed on granulocyte and macrophage precursors but not on pluripotent stem cells.
CD33 serves as a marker for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Dysfunctions of CD33 have been associated with gallbladder lymphoma and extracutaneous mastocytoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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