Thermo Fisher Scientific CD11a Monoclonal Antibody (TS1/22)

Thermo Fisher Scientific CD11a Monoclonal Antibody (TS1/22)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA11A10 targets CD11 alpha in FACS applications and shows reactivity with Human and Mouse samples.
The MA11A10 immunogen is human 180 kD alpha chain of the CD11alpha complex.
MA11A10 detects CD11 alpha which has a predicted molecular weight of approximately 126 kDa.
This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration of ≤10 EU/mg.

Target Information

CD11a (LFA-1 alpha, ITGAL) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the αLβ2 integrin.
CD11a is implicated in activation of the LFA-1 complex and plays a central role in leukocyte intercellular adhesion through interactions with ICAMs 1–3.
It also functions in lymphocyte costimulatory signaling and is expressed on the plasma membrane of leukocytes in a low-affinity conformation.
Cell stimulation by chemokines or other signals induces a high-affinity conformation, supporting tight binding of CD11a to ICAM-1, -2, and -3.
CD11a is involved in immune cell interaction, tissue-specific settlement, cell differentiation, proliferation, and T-cell effector functions.
Blocking CD11a function by specific antibodies or small molecules is an important therapeutic approach for inflammatory diseases.
For example, humanized anti-CD11a antibody Efalizumab (Raptiva) interferes with T-cell migration to inflammation sites, and simvastatin binding to CD11a allosteric site leads to immunomodulation and increased lymphocytic cholinergic activity.
Two transcript variants encoding different isoforms of CD11a have been identified.
Diseases associated with CD11a dysfunction include benign cephalic histiocytosis and leukocyte adhesion deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.