Thermo Fisher Scientific IRAK4 Polyclonal Antibody
IRAK4 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC 등 다양한 응용에 적합. Human 및 Mouse 반응성. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 0.1% sodium azide 포함. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:100 | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the N-terminal region of the human IRAK4 (IL-1 receptor associated kinase 4) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533268 |
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to challenges with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members of the IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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