Thermo Fisher Scientific B7-H4 Monoclonal Antibody (H74), PE, eBioscience
인간 B7-H4 단백질을 검출하는 H74 클론 단일클론 항체로, PE 형광 표지되어 있습니다. Flow cytometry에 최적화되어 있으며, 5 µL/test로 사용 가능합니다. T세포 면역 조절 연구 및 암 관련 바이오마커 분석에 적합합니다.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 정보 없음
- View 1 publication
Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.125 µg)/test
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H74 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1944340 |
Additional Formats
- Unconjugated
- APC
- Biotin
- Functional Grade
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Request custom conjugation
Product Specific Information
The H74 monoclonal antibody reacts with human B7-S1, also known as B7-H4 and B7x. Cross-reactivity to other proteins has not been determined. B7S1 is a newly discovered member of the B7 family and may regulate T cell costimulation depending on B cell activation status. BTLA is reported as a counter receptor, but further studies are needed to confirm the ligand for B7-H4.
H74 stains human B7-H4 transfected cells and not peripheral blood cells. The exact expression pattern of B7-H4 has not been fully characterized.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated and tested on human B7-H4-transfected cells
- Recommended Usage: 5 µL (0.125 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test)
- Excitation: 488–561 nm
- Emission: 578 nm
- Laser Compatibility: Blue, Green, Yellow-Green
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
B7-H4 (B7x, VTCN1) is a costimulatory protein acting as a negative regulator of T-cell mediated immunity. Though its receptor is unknown, it delivers inhibitory signals to T-cells, preventing proliferation, cell cycle progression, and interleukin-2 production.
B7-H4 is expressed on activated T-cells, B-cells, monocytes, and dendritic cells. Aberrant expression is linked to lung, breast, and ovarian cancers. It is primarily membrane-bound on lymphoid cells and may help tumor cells evade immune responses.
VTCN1 is a potential biomarker for early detection of ovarian cancer and renal cell carcinoma (RCC).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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