Thermo Fisher Scientific Laminin beta-2 Polyclonal Antibody
Thermo Fisher Scientific의 Laminin beta-2 Polyclonal Antibody는 인간 시료에 반응하는 토끼 유래 IgG 항체입니다. Western blot과 IHC(P)에서 검증되었으며, 항원 친화 크로마토그래피로 정제되었습니다. PBS, 40% 글리세롤 완충액에 보관되며 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human LAMB2. Recombinant protein control fragment (Product # RP-101042) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789147 |
Product Specific Information
Immunogen sequence:
DLTDVQDENF NANHALSGLE RDRLALNLTL RQLDQHLDLL KHSNFLGAYD SIRHAHSQSA EAERRANTSA LAVPSPVSNS ASARHRTEAL MDAQKEDFNS KHMANQRALG KLSAHTHTLS LTDINELVCG APG
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins.
- A-type lamins include lamin A, lamin C, and lamin Adel 10, derived from the same gene by alternative splicing.
- B-type lamins include lamin B1 and lamin B2, encoded by distinct genes.
Mutations in A-type lamins are associated with rare dominant genetic disorders such as Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease, and Dunnigan-type familial partial lipodystrophy.
A-type lamins are expressed during cell differentiation and interact with chromatin, suggesting a regulatory role in gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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