Thermo Fisher Scientific PAPP-A/Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus) Monoclonal Antibody (PAPPA/2717)
PAPP-A 단백질을 인식하는 단클론 항체로, 죽상동맥경화 및 염색체 이상 태아의 바이오마커 연구에 활용. 인간 시료 반응성, 마우스 IgG2b 아이소타입. IHC 및 Peptide Array에 사용 가능. 단백질 A/G 정제, PBS 버퍼 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PAPPA/2717 |
| Immunogen | Recombinant fragment (within aa 351–523) of human PAPP-A protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Pregnancy-associated plasma protein-A (PAPP-A, also known as insulin-like growth factor binding protein-4 protease or PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein (~500 kDa) first identified in serum from pregnant women.
The heterotetramer consists of two PAPP-A subunits and two proMBP subunits.
Low maternal serum levels of PAPP-A in first trimester biochemical screening are used as a marker of Down’s syndrome (trisomy 21).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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