Thermo Fisher Scientific WIZ Polyclonal Antibody
WIZ 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 시료에 반응합니다. IHC(P) 및 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 용액 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human WIZ. Recombinant protein control fragment (Product #RP-93566) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2649656 |
Product Specific Information
Immunogen sequence:
SPSDLHISPL AKKLPPPPGS PLGHSPTASP PPTARKMFPG LAAPSLPKKL KPEQIRVEIK REMLPGALHG ELHPSEGPWG APREDMTPLN LSSR
Highest antigen sequence identity to the following orthologs:
- Mouse: 89%
- Rat: 93%
Target Information
WIZ, also known as ZNF803, was initially identified in a mouse cerebellum cDNA library screen and its message was found to be expressed in the granule cell layers of the cerebellum as well as in the dentate gyrus and olfactory bulb. Later analysis indicates that WIZ is ubiquitously expressed. WIZ is a nuclear protein that co-localizes with G9a, a histone methyltransferase responsible for mono- and dimethylation of H3K9 at euchromatic regions. WIZ can also associate with CtBP family proteins, known to be transcriptional co-repressors, and has been suggested to link G9a/GLP complexes to the CtBP co-repressor machinery, possibly regulating complex stability and gene silencing.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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