Thermo Fisher Scientific WIZ Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human WIZ. Recombinant protein control fragment (Product #RP-93566). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:WIZ,uniProtId:O95785-1,ncbiNodeId:9606,antigenRange:1127-1220,antigenLength:1651,antigenImageFileName:PA5-54636_WIZ_O95785-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54636_WIZ_O95785-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649656

Product Specific Information

Immunogen sequence: SPSDLHISPL AKKLPPPPGS PLGHSPTASP PPTARKMFPG LAAPSLPKKL KPEQIRVEIK REMLPGALHG ELHPSEGPWG APREDMTPLN LSSR

Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 93%.

Target Information

WIZ, also known as ZNF803, was initially identified in a mouse cerebellum cDNA library screen and its message was found to be expressed in the granule cell layers of the cerebellum as well as in the dentate gyrus and olfactory bulb. Later analysis indicates however that WIZ is ubiquitously expressed. WIZ is a nuclear protein that co-localizes with G9a, a histone methyltransferase responsible for mono- and dimethylation of H3K9 at euchromatic regions. WIZ can also associate with CtBP family proteins, known to be transcriptional co-repressors, and has been suggested to link G9a/GLP complexes to the CtBP co-repressor machinery, possibly regulating complex stability and gene silencing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.