Thermo Fisher Scientific Silencer Select Human Epigenetics siRNA Library

Invitrogen™ Silencer™ Select Human Epigenetics siRNA Library

Epigenetic regulation of gene expression is proving to be key in the development and progression of a host of human diseases.
The Silencer™ Select Human Epigenetics siRNA Library contains 1563 Ambion™ Silencer Select highly potent, chemically modified siRNAs targeting 521 epigenetic enzymes, including those mediating epigenetic signaling through the acetylation and methylation of histones.

This library was designed using the most up-to-date genome databases, including the NCBI RefSeq, Gene Ontology Consortium (GO), and HUGO Gene Nomenclature Committee (HGNC) databases.
Silencer Select siRNAs are designed using Thermo Fisher Scientific’s leading design algorithms and locked nucleic acid (LNA) modifications, ensuring efficacy, specificity, and potency for accurate and consistent phenotype data in RNAi screening against epigenetic gene knockdown studies.

주요 특징

• Superior efficacy — Reduce off-target effects by up to 90% through advanced design algorithms and LNA modifications
• Highest efficiency — Perform knockdown studies with 100-fold more potent siRNAs than conventional siRNAs
• Dependable — Achieve faster discoveries via consistent gene knockdown and reliable phenotypic results
• Convenient — Arrayed format reduces data deconvolution and accelerates target validation
• Customizable — Select from various siRNA scales and pooled formats to fit workflow requirements

Why use the Silencer Select Human Epigenetics siRNA Library?

Together with careful bioinformatics selection of gene targets, Silencer Select siRNAs are optimized using proprietary design algorithms, chemical modifications, and high-quality synthesis to ensure desired RNAi outcomes.
This library contains pre-designed and, when available, validated siRNAs generated for highest potency and specificity, enabling researchers to focus on data quality rather than performance issues.
Thermo Fisher Scientific’s Ambion Silencer Select siRNAs are backed by an industry-leading guarantee.

Maximized Discovery with Highly Potent siRNAs

Ambion Silencer Select siRNAs provide up to 100-fold higher potency, allowing gene knockdowns at the lowest concentrations.
This minimizes off-target effects, reduces false negatives, and maximizes siRNA library output for additional screens and data validation.
Each siRNA is supplied at 0.25 nmol, sufficient for approximately 500 transfections (at 5 nM siRNA, 100 μL transfection volume).

Flexible Options for Workflow Needs

Thermo Fisher Scientific offers comprehensive pre-defined or custom siRNA libraries against human, mouse, or rat genes, available in 1, 2, or 5 nmol sizes or larger.
For complete gene lists or technical support, contact your local sales representative or e-mail: RNAilibraries@lifetech.com

제품 사양

제품 이미지