Thermo Fisher Scientific NAB2 Polyclonal Antibody
NAB2 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 적합합니다. 인간 및 마우스 반응성을 가지며, 액상 형태로 고순도 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific NAB2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NAB2, corresponding to a region within C-terminal amino acids. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850619 |
Product Specific Information
Antibody detects endogenous levels of total NAB2.
Target Information
Transcriptional control is partly regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, act as corepressors of EGF-1/NGFI-A.
Both NAB1 and NAB2 contain:
- N-terminal NAB conserved domain 1 (NCB1): required for binding NGFI-A
- C-terminal NCD2 domain: responsible for the repressor function
NAB2 is mainly localized in the nucleus and may play a role in downregulating NGFI-A activity and controlling processes such as cell division, differentiation, and apoptosis.
NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3–14.1, a region rearranged in several solid tumors, lipomas, and liposarcomas.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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