Thermo Fisher Scientific HERPUD1 Polyclonal Antibody
HERPUD1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC 등 다양한 응용에 적합합니다. Human과 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. ER 스트레스 및 단백질 분해 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 | — |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | — |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | — | 1 publication |
| Immunocytochemistry (ICC/IF) | — | 2 publications |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 9–251 of Human HERPUD1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546945 |
Product Specific Information
- Recommended positive controls: 293T, mouse brain
- Predicted reactivity: Mouse (86%), Rat (83%), Bovine (87%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes:
- Inhibition of translation to prevent further accumulation of unfolded proteins
- Increased expression of proteins involved in folding (unfolded protein response, UPR)
- Degradation of misfolded proteins via the ER-associated protein degradation (ERAD) system
HERPUD1 may play a role in both UPR and ERAD. Its expression is induced by ER stress and contains an ER stress response element in its promoter region. The encoded protein has an N-terminal ubiquitin-like domain that may interact with the ERAD system. HERPUD1 interacts with presenilin proteins and can increase amyloid-beta levels upon overexpression. Alternative splicing produces multiple transcript variants with differing isoforms.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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