Thermo Fisher Scientific MPP10 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MPP10 protein for WB and IP applications. High specificity with predicted cross-reactivity across multiple species. Supplied as liquid form, purified via antigen affinity chromatography, and suitable for resea...
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Thermo Fisher Scientific MPP10 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to amino acids 370–569 of Human MPHOSPH10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.56 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2546941 |
Product Specific Information
- Recommended positive control: MCF-7
- Predicted reactivity: Mouse (96%), Rat (95%), Zebrafish (84%), Rhesus Monkey (100%), Bovine (97%)
- Store product as a concentrated solution. Centrifuge briefly before opening the vial.
Target Information
MPP10 (M-phase phosphoprotein 10), also known as MPHOSPH10, is a 681 amino acid protein localized to the fibrillar region of the nucleolus. It is phosphorylated during the M phase of the cell cycle and forms part of the 60–80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex, essential for early cleavages in pre-18S ribosomal RNA processing.
MPP10 interacts with IMP-3 and IMP-4 to form a heterotrimeric complex required for nucleolar association. The MPP10 gene is located on human chromosome 2, which contains over 500 genes. Mutations in genes on this chromosome have been linked to disorders such as Phelan-McDermid syndrome, Neurofibromatosis type 2, autism, and schizophrenia.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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