Thermo Fisher Scientific KLF17 Polyclonal Antibody
Human KLF17 단백질에 특이적인 Rabbit Polyclonal Antibody로, Western blot에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. PBS 기반 버퍼에 안정화되어 장기 보관 가능. 연구용으로만 사용.
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Applications
- Western Blot (WB): 1:500–1:3,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 1–164 of Human KLF17 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2549247 |
Product Specific Information
- Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7
- Predicted reactivity: Human (98%), Chimpanzee (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
KLF17 is a transcription repressor that binds to the promoter of target genes and prevents their expression. It acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically, it binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and represses its expression. It may also function as a germ cell-specific transcription factor involved in spermatid differentiation and oocyte development.
주의사항
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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