Thermo Fisher Scientific Phospho-c-Myc (Ser62) Monoclonal Antibody (1A7)

Applications and Tested Dilutions

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation at Thr58/Ser62 by kinases such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is functionally associated with cell proliferation and regulation. c-Myc is essential for vasculogenesis and angiogenesis during tumor development.

The c-myc oncogene (p62 c-myc) regulates normal cellular proliferation and differentiation, while deregulated expression induces apoptosis in different cell types. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to target proteins.

Amplification of the c-Myc gene has been observed in several human tumors, including lung, breast, and colon carcinomas. The N-Myc gene is amplified in neuroblastomas. Translocation of the c-myc locus to immunoglobulin loci is associated with Burkitt’s lymphoma and other B-cell lymphoproliferative disorders. Aberrant c-myc expression is found in tumors of diverse origins such as colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.