Thermo Fisher Scientific Phospho-c-Myc (Thr58, Ser62) Monoclonal Antibody (2B11)

Applications

• Western Blot (WB): Tested dilution 1:1,000

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene located on human chromosome 8q24. It is commonly activated in various tumor cells and plays key roles in:

• Cellular proliferation, differentiation, apoptosis, and cell cycle progression
• Phosphorylation at Thr58/Ser62 by GSK3, CDK, ERK2, and JNK, which are associated with cell proliferation and regulation
• Vasculogenesis and angiogenesis in tumor development

Aberrant expression or amplification of the c-Myc gene is linked to multiple human cancers including lung, breast, colon, and neuroblastoma. Translocation of the c-Myc locus is observed in Burkitt’s lymphoma and other B-cell proliferative disorders.

Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either amino- or carboxy-termini of target proteins.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.