Thermo Fisher Scientific Phospho-c-Myc (Thr58, Ser62) Monoclonal Antibody (2B11)
인간 c-Myc 단백질의 Thr58 및 Ser62 인산화 부위를 인식하는 rabbit monoclonal antibody. Western blot에 최적화되어 있으며, 세포 증식 및 암 관련 신호 연구에 활용 가능. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B11 |
| Immunogen | Synthetic peptide derived from human c-Myc (T58+S62), around 50–100aa (phospho T58+S62) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene located on human chromosome 8q24. It is commonly activated in various tumor cells and plays key roles in:
- Cellular proliferation, differentiation, apoptosis, and cell cycle progression
- Phosphorylation at Thr58/Ser62 by GSK3, CDK, ERK2, and JNK, which are associated with cell proliferation and regulation
- Vasculogenesis and angiogenesis in tumor development
Aberrant expression or amplification of the c-Myc gene is linked to multiple human cancers including lung, breast, colon, and neuroblastoma. Translocation of the c-Myc locus is observed in Burkitt’s lymphoma and other B-cell proliferative disorders.
Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either amino- or carboxy-termini of target proteins.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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