Thermo Fisher Scientific PRDM2 Polyclonal Antibody
PRDM2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등에 사용 가능하며, Human, Mouse, Rat 반응성. 고순도 Protein A 정제, 2 mg/mL 농도, PBS buffer에 sodium azide 포함.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified recombinant fusion protein corresponding to amino acids 245–573 of Rat PRDM2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2170139 |
Product Specific Information
- Recommended positive control: Rat B50 brain tumour cell lysate
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PRDM2, a member of the nuclear/histone methyltransferase superfamily, contains an N-terminal PR domain, an Rb-binding motif, eight Kruppel-like zinc finger motifs, a nuclear hormone-receptor binding motif, and a C-terminal PR-domain binding motif.
It is ubiquitously expressed at low levels and exists in two isoforms:
- RIZ1 (280 kDa) containing the PR-domain
- RIZ2 (250 kDa) lacking the PR-domain
PRDM2 acts as a tumor suppressor, playing a key role in cell growth and differentiation. It interacts with Retinoblastoma protein, estrogen receptor, GATA-3, and the TPA-responsive element (MTE) of the Heme-oxygenase-1 gene. Alterations or inactivation through mutations and hypermethylation are observed in various human cancers, suggesting its potential as a biomarker.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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