Thermo Fisher Scientific FBXW7 Polyclonal Antibody
FBXW7 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA에 적합하며 Human, Mouse, Rat 반응성. 고순도 Affinity Chromatography 정제, -20°C 보관, 연구용 전용.
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Thermo Fisher Scientific FBXW7 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (amino acids 231–371 of human FBXW7, UniProt ID: Q969H0-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.38 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914533 |
Product Specific Information
Positive test controls include Jurkat, SH-SY5Y, MCF7, mouse testis, and rat heart.
The target is typically localized in the cytoplasm, nucleus, nucleolus, and nucleoplasm.
Immunogen sequence:
PTGLQEWLKM FQSWSGPEKL LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR IDTNWRRGEL K
Target Information
F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family, characterized by an approximately 40 amino acid F-box motif. These proteins form part of the SCF (SKP1-cullin-F-box) ubiquitin ligase complex, which mediates phosphorylation-dependent ubiquitination.
FBXW7 belongs to the Fbws subclass containing WD40 domains and has 7 tandem WD40 repeats. It binds directly to cyclin E and may target it for ubiquitin-mediated degradation.
Mutations in FBXW7 have been observed in ovarian and breast cancer cell lines, suggesting its involvement in cancer pathogenesis. Multiple transcript variants encoding different isoforms exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-120961_FBXW7_Q969H0-1_Rabbit.svg, PA5-120961_FBXW7_Q969H0-1_Rabbit_PDP.jpeg)
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