Thermo Fisher Scientific TRICK2 (DR5, TRAIL-R2) Polyclonal Antibody
Human DR5/TRAIL-R2 단백질을 표적하는 Rabbit Polyclonal Antibody로, Western blot에 적합. KLH 결합 합성 펩타이드(aa 309-325)를 면역원으로 사용. Protein A로 정제된 액상 형태이며, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 309–325 (EHLLEPAEAERSQRRRL, isoform 1) of human TRICK2 precursor conjugated to KLH at the N-terminus. The same sequence is found in isoform 2 at amino acids 280–296. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL, mediating TRAIL-induced apoptosis. It belongs to the TNF-receptor superfamily and transduces apoptosis signals upon activation by TNFSF10/TRAIL/APO-2L. FADD-deficient mouse studies indicate that FADD is essential for DR5-mediated apoptosis. Two transcript variants encoding different isoforms and one non-coding transcript are known. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in various cell types, with high levels in lymphocytes and spleen. DR5 dysfunction is associated with squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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