Thermo Fisher Scientific TECK Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• In direct ELISAs, less than 1% cross-reactivity with recombinant human TECK is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

Chemokines play an important role in regulating the trafficking of developing T cells within the thymus.
Chemokine C-C thymus expressed chemokine (TECK), also designated chemokine ligand 25 (CCL25), is expressed predominantly in thymic dendritic cells, thymic epithelial cells, and in the small intestine.
TECK, a CCR9 ligand, has suppressive activity against immature subsets of myeloid progenitors stimulated by multiple growth factors.
It delivers signals through CCR9, crucial for the navigation of developing thymocytes.
Bone marrow pre-pro-B cells and cells capable of generating pro-B colonies in the presence of interleukin-7 and Flt-3 ligand migrate to TECK, a response lost in later stages of B cell development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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